8 September 2021 - Late treatment study
A Randomized Pilot Study Using Calcitriol in Hospitalized Patients
et al., Bone, doi:10.1016/j.bone.2021.116175 (Peer Reviewed)
RCT 50 hospitalized patients in the USA, 25 treated with calcitriol, showing significantly improved oxygenation with treatment. Mortality, intubation, ICU admission, and hospitalization time also favored treatment, while not reaching statistical significance with the very small sample size.
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risk of death, 85.7% lower, RR 0.14, p = 0.23, treatment 0 of 25 (0.0%), control 3 of 25 (12.0%), NNT 8.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of mechanical ventilation, 80.0% lower, RR 0.20, p = 0.48, treatment 0 of 25 (0.0%), control 2 of 25 (8.0%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of ICU admission, 37.5% lower, RR 0.62, p = 0.33, treatment 5 of 25 (20.0%), control 8 of 25 (32.0%), NNT 8.3.
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hospitalization time, 40.5% lower, relative time 0.60, p = 0.14, treatment 25, control 25.
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relative Δ SaO2/FiO2, RR 0.14, p = 0.03, treatment 25, control 25.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
Elamir et al., 9/8/2021, Randomized Controlled Trial, USA, North America, peer-reviewed, 9 authors, dosage calcitriol 0.5μg days 1-14.
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