Elamir: A Randomized Pilot Study Using Calcitriol in Hospitalized Patients

Elamir, 50 patient vitamin D late treatment RCT: 86% lower mortality [p=0.23], 38% lower ICU admission [p=0.33], 40% shorter hospitalization [p=0.14], and 86% improved recovery [p=0.03] https://c19p.org/elamir

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A Randomized Pilot Study Using Calcitriol in Hospitalized Patients

Elamir et al., Bone, doi:10.1016/j.bone.2021.116175

8 Sep 2021 Source PDF Share Tweet

RCT 50 hospitalized patients in the USA, 25 treated with calcitriol, showing significantly improved oxygenation with treatment. Mortality, intubation, ICU admission, and hospitalization time also favored treatment, while not reaching statistical significance with the very small sample size.

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risk of death, 85.7% lower, RR 0.14, p = 0.23, treatment 0 of 25 (0.0%), control 3 of 25 (12.0%), NNT 8.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of mechanical ventilation, 80.0% lower, RR 0.20, p = 0.48, treatment 0 of 25 (0.0%), control 2 of 25 (8.0%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of ICU admission, 37.5% lower, RR 0.62, p = 0.33, treatment 5 of 25 (20.0%), control 8 of 25 (32.0%), NNT 8.3.

hospitalization time, 40.5% lower, relative time 0.60, p = 0.14, treatment 25, control 25.

relative Δ SaO₂/FiO₂, RR 0.14, p = 0.03, treatment 25, control 25, primary outcome.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Elamir et al., 8 Sep 2021, Randomized Controlled Trial, USA, peer-reviewed, 9 authors, dosage calcitriol 0.5μg days 1-14.

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This Paper Vitamin D All

Late treatment
is less effective

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