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Vitamin D study #155   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 64% Imp. Relative Risk, 95% CI Mortality (b) 93% Eden: Nutritional parameters and outcomes in patients admitted.. c19vitamind.com/eden.html Favors vitamin D Favors control
8/5 Analysis of outcomes based on serum levels
Eden et al., BMJ Nutrition, Prevention & Health, doi:10.1136/bmjnph-2021-000270 (Peer Reviewed)
Nutritional parameters and outcomes in patients admitted to intensive care with COVID-19: a retrospective single-centre service evaluation
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Retrospective 72 ICU patients in the UK, showing higher mortality with vitamin D deficiency, not reaching statistical significance.
risk of death, 63.9% lower, RR 0.36, p = 0.10, high D levels (≥25nmol/L) 3 of 26 (11.5%), low D levels (<25nmol/L) 8 of 25 (32.0%).
risk of death, 92.9% lower, RR 0.07, p = 0.18, high D levels (≥50nmol/L) 0 of 8 (0.0%), low D levels (<50nmol/L) 11 of 43 (25.6%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Eden et al., 8/5/2021, retrospective, United Kingdom, Europe, peer-reviewed, 5 authors.
Contact: timothy.eden@nhs.net , @TimothyEdenRD , @ShaneMacZ.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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