Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality

Vitamin D study #48 of 131 Meta Analysis

11/25 Analysis of outcomes based on serum levels

De Smet et al., American Journal of Clinical Pathology, doi:10.1093/ajcp/aqaa252 (Peer Reviewed)
Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality

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Retrospective 186 hospitalized patients in Belgium showing that 59% of patients were vitamin D deficient, and that non-vitamin D deficient patients had significantly lower mortality risk, RR 0.26, p = 0.015.

De Smet et al., 11/25/2020, retrospective, Belgium, Europe, peer-reviewed, 5 authors.

risk of death, 70.1% lower, RR 0.30, p = 0.02, high D levels 7 of 77 (9.1%), low D levels 20 of 109 (18.3%), adjusted per study, odds ratio converted to relative risk, >20ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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