Association of vitamin D status with hospital morbidity and mortality in adult hospitalized COVID-19 patients

Vitamin D study #89 of 131 Meta Analysis

3/8 Analysis of outcomes based on serum levels

Charoenngam et al., Endocrine Practice, doi:10.1016/j.eprac.2021.02.013 (Peer Reviewed)
Association of vitamin D status with hospital morbidity and mortality in adult hospitalized COVID-19 patients

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Retrospective 287 hospitalized patients in the USA showing significantly lower mortality with vitamin D sufficiency in elderly patients and patients without obesity; and lower mortality for all patients but not reaching statistical signifance.

Charoenngam et al., 3/8/2021, retrospective, USA, North America, peer-reviewed, 6 authors.

risk of death, 34.1% lower, RR 0.66, p = 0.19, high D levels 12 of 100 (12.0%), low D levels 29 of 187 (15.5%), adjusted per study, odds ratio converted to relative risk, >=30ng/mL.

risk of mechanical ventilation, 37.2% lower, RR 0.63, p = 0.11, high D levels 14 of 100 (14.0%), low D levels 34 of 187 (18.2%), adjusted per study, odds ratio converted to relative risk, >=30ng/mL.

risk of ICU admission, 23.1% lower, RR 0.77, p = 0.14, high D levels 25 of 100 (25.0%), low D levels 56 of 187 (29.9%), adjusted per study, odds ratio converted to relative risk, >=30ng/mL.

risk of death, 58.1% lower, RR 0.42, p = 0.01, high D levels 7 of 57 (12.3%), low D levels 25 of 79 (31.6%), adjusted per study, odds ratio converted to relative risk, >65 years old, >=30ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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