Cervero, 85 patient vitamin D late treatment RCT: 79% lower ICU admission [p=0.2] and 28% lower ARDS [p=0.74] https://c19p.org/cervero
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Beneficial Effect of Short-Term Supplementation of High Dose of Vitamin D3 in Hospitalized Patients With COVID-19: A Multicenter, Single-Blinded, Prospective Randomized Pilot Clinical Trial
et al., Frontiers in Pharmacology, doi:10.3389/fphar.2022.863587
RCT 85 hospitalized patients in Spain, comparing 10,000IU/day vs. 2,000IU/day cholecalciferol, showing beneficial effects of the larger dose.
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risk of death, 7.3% higher, RR 1.07, p = 1.00, treatment 1 of 41 (2.4%), control 1 of 44 (2.3%).
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risk of ICU admission, 78.5% lower, RR 0.21, p = 0.20, treatment 1 of 41 (2.4%), control 5 of 44 (11.4%), NNT 11.
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risk of ARDS, 28.5% lower, RR 0.72, p = 0.74, treatment 4 of 41 (9.8%), control 6 of 44 (13.6%), NNT 26.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Cervero et al., 7/4/2022, Single Blind Randomized Controlled Trial, placebo-controlled, Spain, peer-reviewed, median age 65.0, 10 authors, study period June 2020 - March 2021, dosage 10,000IU days 1-14.
Contact:
mcerveroj@me.com, mcoiras@isciii.es, m.torres@isciii.es.
Late treatment
is less effective
is less effective
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