• 91% of 33 vitamin D treatment studies report positive effects (17 statistically significant in isolation).
• Random effects meta-analysis with pooled effects using the most serious outcome reported shows 80% and 42% improvement for early treatment and for all studies
(RR 0.20 [0.10-0.37] and 0.58 [0.50-0.67]). Results are similar after restriction to 29 peer-reviewed studies
: 83% and 44% (RR 0.17 [0.07-0.42] and 0.56 [0.47-0.67]), and for the 19 mortality results
: 78% and 55% (RR 0.22 [0.12-0.43] and 0.45 [0.32-0.64]).
• Late stage treatment with calcifediol/calcitriol
shows greater improvement compared to cholecalciferol
: 80% versus 39% (RR 0.20 [0.13-0.31] and 0.61 [0.45-0.83]).
arises from many factors including treatment delay, patient population, the effect measured, variants, the form of vitamin D used, and treatment regimens. The consistency of positive results across a wide variety of cases is remarkable.
• Sufficiency studies
show a strong association between vitamin D sufficiency and outcomes. Meta analysis of the 64 studies with pooled effects using the most serious outcome reported shows 57% improvement (RR 0.43 [0.36-0.52]).
• While many treatments
have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 9% of vitamin D treatment studies show zero events in the treatment arm.
• Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. All practical, effective, and safe means should be used. Not doing so increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage.
• All data to reproduce this paper and the sources are in the appendix