Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy

Vitamin D study #117 of 131 Meta Analysis

6/14 Analysis of outcomes based on serum levels

Campi et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06281-7 (Peer Reviewed)
Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy

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Prospective study of 103 hospitalized patients in Italy, showing very high prevalence of vitamin D deficiency, and increased severity for lower vitamin D levels.

Campi et al., 6/14/2021, prospective, Italy, Europe, peer-reviewed, 21 authors.

risk of death for severe patients, 24.3% lower, RR 0.76, p = 0.53, high D levels 6 of 39 (15.4%), low D levels 13 of 64 (20.3%), >20ng/mL.

risk of ICU for severe patients, 53.1% lower, RR 0.47, p < 0.001, high D levels 12 of 39 (30.8%), low D levels 42 of 64 (65.6%), >20ng/mL.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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