Campi, 155 patient vitamin D prophylaxis study: 88% lower severe cases [p<0.0001], 24% lower mortality [p=0.53], and 53% lower ICU admission [p=0.0006] https://c19p.org/campi
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Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy
et al., BMC Infectious Diseases, doi:10.1186/s12879-021-06281-7
Prospective study of 103 hospitalized patients in Italy, showing very high prevalence of vitamin D deficiency, and increased severity for lower vitamin D levels. Vitamin D supplementation was significantly less common for cases.
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risk of severe case, 88.4% lower, OR 0.12, p < 0.001, treatment 31 of 103 (30.1%) cases,
41 of 52 (78.8%) controls, NNT 2.3, case control OR, vitamin D supplementation, hospitalized patients vs. controls, excluded in exclusion analyses:
significant unadjusted differences between groups.
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risk of death for severe patients, 24.3% lower, RR 0.76, p = 0.53, high D levels (≥20ng/ml) 6 of 39 (15.4%), low D levels (<20ng/ml) 13 of 64 (20.3%), NNT 20, cutoff ≥20ng/ml, hospitalized patients, outcome based on serum levels.
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risk of ICU for severe patients, 53.1% lower, RR 0.47, p < 0.001, high D levels (≥20ng/ml) 12 of 39 (30.8%), low D levels (<20ng/ml) 42 of 64 (65.6%), NNT 2.9, cutoff ≥20ng/ml, hospitalized patients, outcome based on serum levels.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Campi et al., 6/14/2021, prospective, Italy, Europe, peer-reviewed, 21 authors, dosage not specified.
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