2/17 Early treatment study
et al., SICOT-J, doi:10.1051/sicotj/2021001 (Peer Reviewed)
Older patients with proximal femur fractures and SARS-CoV-2 infection – An observational study
Older patients with proximal femur fractures and SARS-CoV-2 infection – An observational study
Small retrospective study of 29 hip fracture patients in the UK, 14 with COVID-19. All COVID-19 patients were treated with vitamin D except for 2 where testing and supplementation was missed due to a clerical error. The two COVID-19 patients that died were the two that did not receive vitamin D supplementation.
risk of death, 93.3% lower, RR 0.07, p = 0.01, treatment 0 of 12 (0.0%), control 2 of 2 (100.0%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Burahee et al., 2/17/2021, retrospective, United Kingdom, Europe, peer-reviewed, 4 authors, dosage 100,000IU days 1-4, additional 200000IU over four weeks if serum level insufficient.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical significance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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