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Home   COVID-19 treatment studies for Vitamin D  COVID-19 treatment studies for Vitamin D  C19 studies: Vitamin D  Vitamin D   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Recovery 34% Improvement Relative Risk Recovery (b) 73% Recovery (c) 58% Recovery (d) -6% Recovery (e) -3% c19vitamind.com Bishop et al. NCT04551911 Vitamin D RCT LATE TREATMENT Favors vitamin D Favors control
Bishop, 134 patient vitamin D late treatment RCT: 34% improved recovery [p=0.56] https://c19p.org/bishop
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Results From the REsCue Trial: A Randomized Controlled Trial with Extended-Release Calcifediol in Symptomatic Outpatients with COVID-19
Bishop et al., medRxiv, doi:10.1101/2022.01.31.22270036 (Preprint), NCT04551911 (history)
5 Feb 2022    Source   PDF   Share   Tweet
Small RCT with low-risk patients in Florida, USA, showing no significant differences in overall recovery. Minimal details on outcomes are provided in the preprint. Authors note significantly faster resolution of respiratory symptoms when treatment increased vitamin D levels. Baseline vitamin D was relatively high, mean 37±1 ng/mL, 95% >20ng/mL, leaving little room for improvement. Treatment delay is not specified but is likely relatively late based on the symptoms at baseline, PCR testing delay, and exclusion with FLU-PRO scores <1.5. NCT04551911 (history).
risk of no recovery, 33.7% lower, RR 0.66, p = 0.56, treatment 5 of 65 (7.7%), control 8 of 69 (11.6%), NNT 26, day 21, mid-trial.
risk of no recovery, 73.5% lower, RR 0.27, p = 0.37, treatment 1 of 65 (1.5%), control 4 of 69 (5.8%), NNT 23, day 35.
risk of no recovery, 57.5% lower, RR 0.42, p = 0.44, treatment 2 of 65 (3.1%), control 5 of 69 (7.2%), NNT 24, day 28.
risk of no recovery, 6.2% higher, RR 1.06, p = 0.85, treatment 17 of 65 (26.2%), control 17 of 69 (24.6%), day 14.
risk of no recovery, 3.0% higher, RR 1.03, p = 1.00, treatment 33 of 65 (50.8%), control 34 of 69 (49.3%), day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bishop et al., 5 Feb 2022, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 11 authors, study period 2 November, 2020 - 27 August, 2021, dosage calcifediol 300μg day 1, 60μg days 4-27, trial NCT04551911 (history).
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Late treatment
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