1 January 2022 - Late treatment study
Does Vitamin D Supplementation Reduce Cytokine Storm and Mortality in Geriatric Intensive Care Patients Diagnosed with COVID-19
et al., Journal of Contemporary Medicine, doi:10.16899/jcm.990057 (Peer Reviewed)
Retrospective 80 elderly ICU patients in Turkey, 40 with vitamin D levels <30ng/ml received vitamin D treatment, showing no significant differences in outcomes. Although not statistically significant, results favored treatment which suggests that supplemention was beneficial because low vitamin D levels are typically associated with worse results.
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risk of death, 23.1% lower, RR 0.77, p = 0.26, treatment 20 of 40 (50.0%), control 26 of 40 (65.0%), NNT 6.7.
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risk of mechanical ventilation, 3.3% lower, RR 0.97, p = 1.00, treatment 29 of 40 (72.5%), control 30 of 40 (75.0%), NNT 40.
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risk of no weaning from intubation, 20.4% lower, RR 0.80, p = 0.13, treatment 20 of 29 (69.0%), control 26 of 30 (86.7%), NNT 5.6.
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ICU time, 10.3% lower, relative time 0.90, p = 0.44, treatment 40, control 40.
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hospitalization time, 2.9% lower, relative time 0.97, p = 0.98, treatment 40, control 40.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
This study is excluded in meta analysis:
control group formed from patients with high vitamin D levels.
Bilir et al., 1/1/2022, retrospective, Turkey, Europe, peer-reviewed, 7 authors, study period March 2021 - July 2021, dosage 50,000IU days 1, 8.
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