Selenium, zinc, and vitamin D supplementation affect the clinical course of COVID-19 infection in Hashimoto’s thyroiditis
8th treatment shown to reduce risk in
October 2020 *, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
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Retrospective 356 Hashimoto's thyroiditis outpatients, 270 taking vitamin D, zinc, and selenium, showing significantly lower hospitalization with treatment. Authors adjust for age, gender, BMI, and smoking status, reporting statistically significant associations with p<0.001 for hospitalization and mechanical ventilation, however they do not report the adjusted risks.
29 studies are RCTs, which show efficacy with
p=0.0000035.
This study is excluded in the after exclusion results of meta
analysis:
excessive unadjusted differences between groups.
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risk of mechanical ventilation, 97.4% lower, RR 0.03, p < 0.001, treatment 0 of 270 (0.0%), control 9 of 86 (10.5%), NNT 9.6, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
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risk of hospitalization, 99.0% lower, RR 0.010, p < 0.001, treatment 0 of 270 (0.0%), control 24 of 86 (27.9%), NNT 3.6, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
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risk of severe case, 99.5% lower, RR 0.005, p < 0.001, treatment 0 of 270 (0.0%), control 51 of 86 (59.3%), NNT 1.7, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Asimi et al., 22 May 2021, retrospective, Bosnia and Herzegovina, preprint, 3 authors, dosage 2,000IU daily, this trial uses multiple treatments in the treatment arm (combined with zinc and selenium) - results of individual treatments may vary.
Abstract: See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/351652823
Selenium, zinc, and vitamin D supplementation affect the clinical course of
COVID-19 infection in Hashimoto s thyroiditis
Article in Endocrine Abstracts · May 2021
DOI: 10.1530/endoabs.73.PEP14.2
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Zelija Velija Asimi
Almira Hadžović-Džuvo
Sarajevo School of Science and Technology, Medical school
University of Sarajevo
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Djinan Al-Tawil
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PEP14.2
Selenium, zinc, and vitamin D supplementation affect the clinical course of COVID-19 infection in
Hashimoto's thyroiditis
Zelija Velija Asimi1,2, Almira Hadzovic-Dzuvo1,3, Djinan Al-Tawil1
1Outpatient Clinic with a Daily hospital "Dr Al Tawil", Sarajevo, 2Sarajevo Medical School, SSST University, 3Sarajevo University,
Bosnia and Herzegovina
Adequate supply of zinc, selenium, and vitamin D is essential
for resistance to other viral infections, immune function, and
reduced inflammation. Low levels of micronutrients are
associated with adverse clinical outcomes during viral
infections. Vitamin D improves the physical barrier against the
virus and stimulates the production of antimicrobial peptides. It
can prevent cytokine storms by reducing the production of
inflammatory cytokines. Selenium enhances the function of
cytotoxic effector cells. Furthermore, selenium is important for
maintaining T cell maturation and function, as well as for
producing T cell-dependent antibodies.
Our goal was to determine the effects of selenium, zinc, and
vitamin D supplementation on recovery from COVID-19 in
patients with pre-existing Hashimoto’s thyroiditis.
CONCLUSION
For the treatment of people with Hashimoto’s
thyroiditis who become infected with COVID-19,
the addition of selenium, zinc, and vitamin D3
could be beneficial. Randomized controlled trials
and large population studies should be performed
to evaluate these recommendations.
Reference:
1.
Alexander J, Tinkov A, Strand TA, Alehagen U, Skalny A, Aaseth J. Early
Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral
Resistance Against Progressive COVID-19. Nutrients. 2020 Aug 7;12(8):2358. doi:
10.3390/nu12082358. PMID: 32784601; PMCID: PMC7468884.
2.
Bae M, Kim H. Mini-Review on the Roles of Vitamin C, Vitamin D, and
Selenium in the Immune System against COVID-19. Molecules. 2020 Nov
16;25(22):5346. doi: 10.3390/molecules25225346
3.
Im JH, Je YS, Baek J, Chung MH, Kwon HY, Lee JS. Nutritional status of
patients with COVID-19. Int J Infect Dis. 2020 Nov;100:390-393. doi:
10.1016/j.ijid.2020.08.018. Epub 2020 Aug 11.
4.
Heller RA, Sun Q, Hackler J, Seelig J, Seibert L, Cherkezov A, Minich WB,
Seemann P, Diegmann J, Pilz M, Bachmann M, Ranjbar A,..
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