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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality, ITT, day 28 30% Improvement Relative Risk Mortality, PP, day 28 38% Mortality, ITT, day 14 61% Mortality, PP, day 14 65% Vitamin D  COVIT-TRIAL  EARLY TREATMENT  RCT Is early treatment with vitamin D beneficial for COVID-19? RCT 254 patients in France (April - December 2020) Lower mortality with vitamin D (not stat. sig., p=0.29) c19early.org Annweiler et al., PLoS Medicine, May 2022 Favors high dose Favors low dose

High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial

Annweiler et al., PLoS Medicine, doi:10.1371/journal.pmed.1003999, COVIT-TRIAL, NCT04344041
May 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
RCT comparing single dose 400,000IU and single dose 50,000IU vitamin D in France, showing lower mortality with the higher dose, statistically significant only at day 14.
The aHR for days 0-5 was 1.30 [0.31-5.35], compared to 0.11 [0.02-0.52] for days 6-14, which in part may reflect the conversion delay for cholecalciferol treatment. The lower efficacy at day 28 vs. day 14 may in part reflect use of only a single dose.
risk of death, 30.0% lower, HR 0.70, p = 0.29, treatment 19 of 126 (15.1%), control 21 of 126 (16.7%), Cox proportional hazards, day 28, intention-to-treat.
risk of death, 38.0% lower, HR 0.62, p = 0.17, treatment 17 of 121 (14.0%), control 21 of 121 (17.4%), Cox proportional hazards, day 28, per-protocol.
risk of death, 61.0% lower, HR 0.39, p = 0.049, treatment 8 of 127 (6.3%), control 14 of 127 (11.0%), Cox proportional hazards, day 14, intention-to-treat.
risk of death, 65.0% lower, HR 0.35, p = 0.03, treatment 7 of 122 (5.7%), control 14 of 122 (11.5%), Cox proportional hazards, day 14, per-protocol.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Annweiler et al., 31 May 2022, Randomized Controlled Trial, France, peer-reviewed, 17 authors, study period 15 April, 2020 - 17 December, 2020, dosage 400,000IU single dose, trial NCT04344041 (history) (COVIT-TRIAL).
This PaperVitamin DAll
High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial
Cédric Annweiler, Mélinda Beaudenon, Jennifer Gautier, Justine Gonsard, Sophie Boucher, Guillaume Chapelet, Astrid Darsonval, Bertrand Fougère, Olivier Guérin, Marjorie Houvet, Pierre Ménager, Claire Roubaud-Baudron, Achille Tchalla, Jean-Claude Souberbielle, Jérémie Riou, Elsa Parot-Schinkel, Thomas Célarier
PLOS Medicine, doi:10.1371/journal.pmed.1003999
¶ Membership of the COVIT-TRIAL study group is provided in S1 Supplemental Appendix.
Supporting information S1
References
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