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0 0.5 1 1.5 2+ Mortality, ITT, day 28 30% Improvement Relative Risk Mortality, PP, day 28 38% Mortality, ITT, day 14 61% Mortality, PP, day 14 65% c19vitamind.com Annweiler et al. NCT04344041 COVIT-TRIAL Vitamin D RCT EARLY Favors high dose Favors low dose
Annweiler, 254 patient vitamin D early treatment RCT: 30% lower mortality [p=0.29] https://c19p.org/annweiler4
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High-dose versus standard-dose vitamin D supplementation in older adults with COVID- 19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial
Annweiler et al., PLoS Medicine, doi:10.1371/journal.pmed.1003999, COVIT-TRIAL, NCT04344041 (history)
31 May 2022    Source   PDF   Share   Tweet
RCT comparing single dose 400,000IU and single dose 50,000IU vitamin D in France, showing lower mortality with the higher dose, statistically significant only at day 14.
The aHR for days 0-5 was 1.30 [0.31-5.35], compared to 0.11 [0.02-0.52] for days 6-14, which in part may reflect the conversion delay for cholecalciferol treatment. The lower efficacy at day 28 vs. day 14 may in part reflect use of only a single dose.
risk of death, 30.0% lower, HR 0.70, p = 0.29, treatment 19 of 126 (15.1%), control 21 of 126 (16.7%), Cox proportional hazards, day 28, intention-to-treat.
risk of death, 38.0% lower, HR 0.62, p = 0.17, treatment 17 of 121 (14.0%), control 21 of 121 (17.4%), Cox proportional hazards, day 28, per-protocol.
risk of death, 61.0% lower, HR 0.39, p = 0.049, treatment 8 of 127 (6.3%), control 14 of 127 (11.0%), Cox proportional hazards, day 14, intention-to-treat.
risk of death, 65.0% lower, HR 0.35, p = 0.03, treatment 7 of 122 (5.7%), control 14 of 122 (11.5%), Cox proportional hazards, day 14, per-protocol.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Annweiler et al., 31 May 2022, Randomized Controlled Trial, France, peer-reviewed, 17 authors, dosage 400,000IU single dose, trial NCT04344041 (history) (COVIT-TRIAL).
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