Retrospective study finding that regular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly.
For those receiving regular supplementation:
Adjusted mortality hazard ratio with supplementation HR 0.07,
p = 0.017.
Risk of severe COVID-19 with supplementation OR 0.08,
p = 0.033.
For supplementation started after COVID-19 diagnosis:
Adjusted mortality hazard ratio HR 0.37,
p = 0.28.
Risk of severe COVID-19 with supplementation OR 0.46,
p = 0.4.
risk of death, 93.0% lower, RR 0.07, p = 0.02, treatment 2 of 29 (6.9%), control 10 of 32 (31.2%), NNT 4.1, adjusted per study, regular bolus supplementation.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Annweiler et al., 11/2/2020, retrospective, France, Europe, peer-reviewed, mean age 88.0, 7 authors, dosage 50,000IU monthly, dose varies - 50,000 IU/month, or 80,000IU/100,000IU every 2–3 months.