Annweiler, 61 patient vitamin D prophylaxis study: 93% lower mortality [p=0.02] https://c19p.org/annweiler2
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Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study
et al., Nutrients, doi:10.3390/nu12113377
Retrospective study finding that regular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly.For those receiving regular supplementation:Adjusted mortality hazard ratio with supplementation HR 0.07, p = 0.017.
Risk of severe COVID-19 with supplementation OR 0.08, p = 0.033.For supplementation started after COVID-19 diagnosis:Adjusted mortality hazard ratio HR 0.37, p = 0.28.
Risk of severe COVID-19 with supplementation OR 0.46, p = 0.4.
Risk of severe COVID-19 with supplementation OR 0.08, p = 0.033.For supplementation started after COVID-19 diagnosis:Adjusted mortality hazard ratio HR 0.37, p = 0.28.
Risk of severe COVID-19 with supplementation OR 0.46, p = 0.4.
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risk of death, 93.0% lower, RR 0.07, p = 0.02, treatment 2 of 29 (6.9%), control 10 of 32 (31.2%), NNT 4.1, adjusted per study, regular bolus supplementation.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Annweiler et al., 11/2/2020, retrospective, France, Europe, peer-reviewed, mean age 88.0, 7 authors, dosage 50,000IU monthly, dose varies - 50,000 IU/month, or 80,000IU/100,000IU every 2–3 months.
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