Vitamin D Status is Associated With In-hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients

Vitamin D study #64 of 126 Meta Analysis

1/9 Analysis of outcomes based on serum levels

Angelidi et al., Mayo Clinic Proceedings, doi:10.1016/j.mayocp.2021.01.001 (Peer Reviewed)
Vitamin D Status is Associated With In-hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients

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Retrospective 144 patients in the USA showing significantly lower mortality for vitamin D levels >=30ng/mL.

Angelidi et al., 1/9/2021, retrospective, USA, North America, peer-reviewed, 8 authors.

risk of death, 88.0% lower, RR 0.12, p = 0.01, high D levels 6 of 65 (9.2%), low D levels 20 of 79 (25.3%), adjusted per study, >30ng/mL, supplementary table 2, multivariable logistic regression model 5.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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