Retrospective 464 patients in United Arab Emirates showing low D levels at first hospital visit associated with higher COVID-19 severity and mortality.
AlSafar et al., 5/19/2021, retrospective, United Arab Emirates, Middle East, peer-reviewed, 8 authors.
risk of death, 59.3% lower, RR 0.41, p = 0.05, high D levels 16 of 337 (4.7%), low D levels 10 of 127 (7.9%), adjusted per study, odds ratio converted to relative risk, >=12ng/mL.
risk of COVID-19 severe case, 33.2% lower, RR 0.67, p = 0.005, high D levels 337, low D levels 127, adjusted per study, odds ratio converted to relative risk, >=12ng/mL.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.