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Vitamin D study #99 of 109
5/21 Late treatment study
Alcala-Diaz et al., Nutrients, doi:10.3390/nu13061760 (Peer Reviewed)
Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study
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Retrospective 537 patients in Spain, 79 treated with calcifediol, showing significantly lower mortality with treatment. The treated group had a higher risk of comorbidity, whereas the control group had lower O2 saturation, higher CURB‐65, and higher ARDS (serverity measures were included in the multivariate analysis).

Alcala-Diaz et al., 5/21/2021, retrospective, Spain, Europe, peer-reviewed, 17 authors, dosage calcifediol 0.5mg day 1, 0.27mg day 3, 0.27mg day 7, 0.27mg day 14, 0.27mg day 21, 0.27mg day 28.
risk of death, 80.8% lower, RR 0.19, p = 0.02, treatment 4 of 79 (5.1%), control 90 of 458 (19.7%), adjusted per study, odds ratio converted to relative risk, day 30, multivariate logistic regression.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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