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Vitamin D study #183   Meta Analysis
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Severe case 68% Imp. Relative Risk, 95% CI Al-Anouti: Associations between Genetic Variants in the Vitamin D M.. c19vitamind.com/alanouti.html Favors vitamin D Favors control
10/20 Analysis of outcomes based on serum levels
Al-Anouti et al., Nutrients, doi:10.3390/nu13113680 (Peer Reviewed)
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
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Retrospective 646 COVID-19 patients in the UAE, showing significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity, and an association with vitamin D deficiency and COVID-19 severity. Patients in this study overlap with [1]. DOH/DQD/2020/538.
risk of severe case, 68.1% lower, RR 0.32, p < 0.001, high D levels 56 of 146 (38.4%), low D levels 52 of 142 (36.6%), adjusted per study, odds ratio converted to relative risk, <12ng/ml vs. >20ng/ml.
Al-Anouti et al., 10/20/2021, retrospective, United Arab Emirates, Middle East, peer-reviewed, 11 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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